Blar i forfatter "Sun, Baojian"
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Adjuvant activity of fish type I interferon shown in a virus DNA vaccination model
Chang, Chia Jung; Sun, Baojian; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-09)There is a need for more efficient vaccines to combat viral diseases of Atlantic salmon and other farmed fish. DNA vaccines are highly effective against salmonid rhabdoviruses, but have shown less effect against other viruses. In the present work we have studied if type I IFNs might be used as adjuvants in fish DNA vaccines. For this purpose we chose a DNA vaccine model based on the hemagglutin ... -
Atlantic salmon possesses two clusters of type I interferon receptor genes on different chromosomes, which allows for a larger repertoire of interferon receptors than in zebrafish and mammals
Sun, Baojian; Greiner-Tollersrud, Linn; Koop, Ben F; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Protection of Atlantic salmon against virus infection by intramuscular injection of IFNc expression plasmid
Chang, Chia Jung; Robertsen, Camilla; Sun, Baojian; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-02)n this work we have tested the in vivo antiviral activity of type I interferons (IFNs) in Atlantic salmon by injecting presmolts intramuscularly (i.m.) with plasmids encoding IFNa1, IFNb or IFNc under the control of a CMV promoter, and measured expression of antiviral genes in organs and protection against infection with infectious salmon anemia virus (ISAV)infection. Allthree IFN plasmids induced ... -
Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
Sobhkhez, Mehrdad; Skjesol, Astrid; Thomassen, Ernst Ivan; Iliev, Dimitar Borisov; Sun, Baojian; Robertsen, Børre; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Mammalian IRF9 and STAT2, together with STAT1, form the ISGF3 transcription factor complex, which is critical for type I interferon (IFN)-induced signaling, while IFNγ stimulation is mediated by homodimeric STAT1 protein. Teleost fish are known to possess most JAK and STAT family members, however, description of their functional activity in lower vertebrates is still scarce. In the present study we ...